Derivative work

Segovia-Juarez, J., Ganguli, S., and Kirschner, D. Identifying control mechanisms of granuloma growth during M. tuberculosis infection using an agent based model. Journal of Theoretical Biology. Vol 231, No. 3, Pages: 357-376. 2004.

  1. Deo J. (2009) Modelling TB and Atherosclerosis using Multi-Agents. Thesis. Department of Computing, Imperial College London. http://www.doc.ic.ac.uk/teaching/distinguished-projects/2009/j.deo.pdf

"Segovia et al undertook an agent based model defined in [1], which allowed them to define the individual interactions among entities at the cellular level and observe the dynamics between these entities at the tissue level. In this project I re-implemented their C/C++ implementation using Java and was able to obtain similar results.

I then used this approach to model for the first time, atherosclerosis in a mouse. The current body of literature has little quantitative analysis of atherosclerosis in humans. Murine models are essential for testing mechanistic hypotheses in a controlled manner and are a good surrogate for studies of human diseases".

  1. Simeone Marino, Caitlin Hult, Paul Wolberg, Jennifer J. Linderman, Denise E. Kirschner, The Role of Dimensionality in Understanding Granuloma Formation, Computation 2018, 6(4), 58, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599587/. 3D version of the model.

  2. Sershen Cheryl L., Plimpton Steven J., May Elebeoba E., Oxygen Modulates the Effectiveness of Granuloma Mediated Host Response to Mycobacterium tuberculosis: A Multiscale Computational Biology Approach, Frontiers in Cellular and Infection Microbiology, 6, 2016. URL=https://www.frontiersin.org/article/10.3389/fcimb.2016.00006

    "We developed our core ABM in the manner of Segovia-Juarez et al. (2004) and Ray et al. (2009) using the supplementary Materials and rules from the Ray et al. model (included in Ray et al., 2009 Supplement 1)"

  3. Modelling the effects of bacterial cell state and spatial location on tuberculosis treatment: Insights from a hybrid multiscale cellular automaton model Ruth Bowness, Mark A.J. Chaplain, Gibin G. Powathil, Stephen H. Gillespie J Theor Biol. 2018 Jun 7; 446: 87–100.